Diselenide-Containing Hyperbranched Polymer with Light-Induced Cytotoxicity

Chenxing Sun, Shaobi Ji, Feng Li and Huaping Xu

ACS Appl. Mater. Interfaces, 20179, 12924–12929.

A light-induced cytotoxicity system was fabricated using active diselenide/porphyrin-containing hyperbranched polymer aggregates in aqueous solution through emulsification. When the nanoparticles were irradiated with visible light, 1O2 was produced by the porphyrin photosensitizers in the system, which cleaved the diselenide bonds in the polymer chains and disassembled the nanosystem. Interestingly the oxidized products exhibited cytotoxicity to the MDA-MB 231cell line without using extra anticancer drugs, which endowed the system with potential visible light-induced anti-tumour activity. In combination with photodynamic therapy, it is greatly anticipated that better anticancer efficacy can be achieved with this system.