Selenium-functionalized Metal-Organic Frameworks for Enzyme Mimics

Weiqiang Zhou, Hongfeng Li, Bin Xia, Wenlan Ji, Shaobo Ji, Weina Zhang, Wei Huang, Fengwei Huo and Huaping Xu

Nano Res., 2017, DOI 10.1007/s12274-017-1623-2

The development of artificial enzyme mimics has been rapidly growing and attracting more and more attention owing to their remarkable advantages over natural enzymes. Herein, we developed a general and facile method to fabricate an efficient glutathione peroxidase (GPx) mimic by grafting the selenium-containing molecule (phenylselenylbromide: PhSeBr) to the framework of Zr(IV)-based UiO-66-NH2 (UiO-66-Se). With glutathione (GSH) serving as the substrate, the fabricated catalysts can catalyze the reduction of hydroperoxides. The as-prepared UiO-66-Se system shows good catalytic activity over three cycles. The high-efficiency GPx mimic MOFs with excellent thermal and structural stability will provide a promising avenue for the development of artificial enzyme mimics.