Selenium–Platinum Coordination Dendrimers with Controlled Anti-Cancer Activity

Tianyu Li, Mario Smet, Wim Dehaen, and Huaping Xu

ACS Appl. Mater. Interfaces, 20168, 3609-3614.

Dendrimers are considered as good vectors for drug delivery in cancer treatment. However, most anticancer drugs are conjugated to the peripheral surface of dendrimers, sacrificing the advantages of monodispersity and stability belonging to dendrimers. Furthermore, dendrimers in current studies of cancer treatment are mostly used as vectors for drugs, whereas the anticancer activity of dendrimers on their own is less studied. Here we have prepared monodisperse selenium–platinum coordination dendrimers with a selenium–platinum core buried inside. Structures of the dendrimers were determined by various characterizations. The coordination dendrimers showed controlled anticancer activity by themselves, without loading additional drugs. The in vivo study further demonstrated their anticancer activity and low toxicity to normal tissues.