Luo Zhang, Chenxing Sun, Yizheng Tan and Huaping Xu
CCS Chem., 2021, DOI: 10.31635/ccschem.021.202101203.
Thioredoxin reductase (TrxR) is an essential enzyme for regulating the redox balance in cells, promoting cell proliferation, and inhibiting cell apoptosis. The biochemical pathway of TrxR metabolism involves a series of selenium-sulfur (Se-S) dynamic chemistry. Theoretically, nanomaterials with Se-S dynamic bonds could exhibit TrxR-mimetic activities to tune TrxR activity and thus affect the cell activities. Herein, we report the selenium-sulfur-doped carbon dots (Se-S-CDs) synthesized by a facile hydrothermal method. The Se-S-CDs exhibited good stability and solubility in aqueous solution with a quantum yield of 13.27%. The doping of Se-S bonds endows the Se-S-CDs with great capability of enhancing the TrxR activity and the consequent remarkable promotion of cell viability. The significance of Se-S bonds as well as the carbon dots as matrix were discussed. Moreover, the Se-S-CDs could also revive the cells from the damage induced by oxidative stress. The abovementioned properties demonstrated the potential of the Se-S-CDs for cells and tissues culturing, solving the poor cell viability issue which is desperately needed for organ transplantation, and revitalizing prematurely aging cells especially those exposed to oxidative stress.