Chengfei Liu, Yifan Jin, Jiahui Ma, Wei Tian*, Huaping Xu*
Chinese J. Polym. Sci.; 2025, 10.1007/s10118-025-3341-7
Intracellular polymerization is an emerging field, showcasing high diversity and efficiency of chemistry. Motivated by the principles of natural biomolecular synthesis, polymerization within living cells is believed to be a powerful and versatile tool to modulate cell behavior. In this review, we summarized recent advances and future trends in the field of intracellular polymerization, specifically focusing on covalent and supramolecular polymerization. This discussion comprehen...
More
Author: wanglu
Prof. Huaping Xu attended ACS Spring 2025 as plenary spearker
Prof. Huaping Xu was invited to deliver a plenary lecture on Polymers for Biomedical Applications as part of the ACS Meetings Global Virtual Symposia (GVS) Spring 2025 session, held in March 2025.
More
Functional Heteroatom Substituted Hyperbranched Polymers: Recent Developments and Perspectives
Yuanbo Zhang, Chaowei He, Huaping Xu*
ACS Appl. Mater. Interfaces; 2025, doi.org/10.1021/acsami.4c22844.
Heteroatom-substituted hyperbranched polymers (HBPs) have emerged as a versatile class of functional materials, combining the structural merits of hyperbranched architectures with the unique chemical functionalities imparted by heteroatoms such as boron, silicon, phosphorus, sulfur, selenium, and tellurium. These polymers exhibit distinct physicochemical properties, including low viscosity, excellent solubility, high chemical reactivity, and tunable functionality, which position them as...
More
Scholarships and prizes of Xu’s group in 2024
Happy New Year！
Prof. Maria Vamvakaki visited Tsinghua University and gave a lecture
On October 22th, 2024, Prof. Maria Vamvakaki from the University of Crete visited Tsinghua University and delivered a lecture on her research.
Prof. Maria Vamvakaki is a professor at Department of Materials Science and Engineering of University of Crete and an affiliated Faculty Member at Institute of Electronic Structure and Laser of the Foundation for Research and Technology. She holds a doctoral degree in Polymer Chemistry from University of Sussex, UK. Next, she became a post-doctoral associate at University of Sussex, and then a Visiting Assistant Professor at University of Cyprus. Her c...
More
Mini Symposium on Dynamic Polymers
On 28th Sep, our group organized a mini symposium on dynamic polymers at Biomedical Building E203 in Tsinghua University, with many famous professors invited. The content of the symposium is as follows：
The discuss atmosphere of the symposium was very hot, the professors and students exchanged their minds passionately. More photos can be seen in GALLERY.
More
Assembly Regulates Gamma Radiation Polymerization of Polytelluoxane
Shenghan Zhang, Yijie Lu, Junjie Song, Jun Guan, Yiheng Dai, Wei Cao*, and Huaping Xu*
Angew. Chem. Int. Ed.; 2024, e202415811
Regulating chemical drug's responsiveness to gamma radiation is crucial for achieving better therapeutic effects in cancer treatment. Most research focused on thermodynamic chemical structure design, while little attention was paid to kinetic regulate strategy, which possesses greater universality and security. In this study, we achieved a kinetic-based regulate strategy of gamma radiation reaction, through the construction of microphase environment during polymeri...
More
Intracellular Construction of Topological Polymer Networks to Destruct Organelles
Chengfei Liu, Banruo Xianyu, Chaowei He, Muqing Cao, Zhuolin Chen, Tianyu Li and Huaping Xu*
CCS Chem.; 2024, 10.31635/ccschem.024.202404842
Topological polymers play a major role in their interaction with intracellular organelles to affect their cellular activities owing to their large surface area and multilevel branched structures. Yet, the existing studies on these polymers mainly focus on the topochemical polymerization outside the cells and how these topological polymers interact with the cell outer membrane. Herein, we established an intracellular topological polymerization based ...
More
S-Se-S type molecule: A bactericidal promoter against H2S-induced antibiotic resistance
Mengnan Liu1, Fanqiang Bu1, Guofeng Li, Wensheng Xie, Huaping Xu*, Xing Wang*
The Innovation Life.; 2024, 2, 100076
The hydrogen sulfide (H2S)-induced defense system is a crucial bacterial pathway that leads to antibiotic resistance. Herein, a unique S-Se-S molecule, namely, 2,2’-(selenobis(sulfanediyl))diacetic acid (Se-Acid), is first reported to relieve H2S-induced antibiotic resistance by acting as a hydrogen selenide (H2Se) donor. The S-Se-S molecular structure was formed using the carboxyl terminal as an electron acceptor. After being endocytosed by cells, Se-Acid effectively released ...
More