Qiliang Yin. Jingjing Li, Jianhua Zhang, Jiyan Leng, Kexin Zhang, Xihui Gao, Fan Wang*, Qi Yue*, Chao Ma*, Huaping Xu, Xiaogang Liu, Hongjie Zhang, Kai Liu* Nano Letters, 2025. 25(36): p. 13629-13638. Despite advances in immunotherapy, its efficacy against postoperative glioma recurrence remains limited. Here, we present a neoantigen-targeting peptide nanoshield that synergizes with glioma resection to eliminate residual tumor cells and prevent relapse. The nanoshield architecture is constructed using a multicationic protein (MCP) as the structural scaffold, which is assembled with the mutat...

Mo Zhai, Banruo Xianyu, Honglin Zhang, Xiaoqiang Bai, Yang Fu, Zhuqing Wan, Wenke Zhang, Huaping Xu*, Yongsheng Zhou*, Longwei Lv*  Adv. Funct. Mater. 2025: e14534. Titanium implants, although widely used in clinical applications, are still facing challenges of inflammation and compromised osseointegration, especially in diabetic and osteoporotic patients. Existing titanium modification techniques are confronted with problems of complicated manufacturing processes, poor bonding strength, and difficulties in dual regulation of immunity and osteogenesis. Here, a selenium-containing polyurethan...

Wei Chen, Hanjie Zhu,  Ruotong Deng, Yuqing Qiao, Qing Ruan, Junbo Zhang, Yongxian Zhang, Yantao Niu, Huaping Xu*, Wei Cao* Cell Biomaterials. 2025 Radiation-induced intestine injury is a common clinical complication in radiotherapy for abdominal and pelvic cancers. To date, oral radioprotective agents are still extremely rare because the harsh gastrointestinal environment would denature the drugs. Melanin, a natural polymer, has attracted attention for its potential radioprotective properties. However, the inherent low Z elements in natural melanin offer limited defense against radiation en...

Jianbing Liu, Peng Zhao, Yizheng Tan*, Huaping Xu* Supramolecular Materials, 2025: p. 100115. Fluorescent polymeric materials have recently gained significant attention in diverse fields, including biological imaging, luminescent sensing, encryption, and anti-counterfeiting. However, the patterning of many materials mentioned above has primarily been achieved through soft lithography technology using ultraviolet light, which can cause unnecessary damage to the materials and is limited by a shallow penetration depth. Herein, we introduce oligo(p-phenylene vinylene) derivatives (cyano-OPVs) as...

Cheng Liu, Chaowei He, Xiaobin Dai, Li-Tang Yan*, Huaping Xu* Adv. Mater. 2025: e08549. Can artificial polymer materials exhibit the characteristic of “evolution” over time, similar to biological tissue? The limitations arise from their inherently static nature and the absence of dynamic structures. A strategy is proposed for designing polymer materials whose phases and mechanical properties can be continuously transformed and enhanced temporally. Specifically, the polymer phases experience a sequence of transitions involving generation, separation, and fusion. Each period enhances mechanica...

Zhuoxin Ge, Yizheng Tan*, Huaping Xu* Polym. Sci. Technol. 2025 In recent decades, significant advancements have been achieved in the field of polymer self-assembly. Among various polymer assemblies, the unique chemical properties of selenium and tellurium have established a robust foundation for the development of functional polymer assemblies that incorporate these elements. Polymer assemblies containing selenium and tellurium have garnered significant attention due to their sensitive responsiveness to stimuli and their precise biological functions. In this review, we summarize the resea...

Ruotong Deng, Wei Chen, Hanjie Zhu, Yuxi Li, Yining Ou, Jian Wang, Qing Ruan, Xuanying Zhang, Junbo Zhang, Yongxian Zhang, Yantao Niu, Zhubin Hu, Chunlei Zhang, Huaping Xu*, Wei Cao* Nat Commun.; 2025, 16, 7895 The escalating utilization of ionizing radiation across medicine and industry underscored the paramount urgency of effective radioprotective materials. Conventional materials such as lead and concrete are widely used, and lead-free materials have also emerged to solve the problems of cumbersome and toxic lead, such as metal-containing micro/nano materials and polymers. Nevertheless, t...

Ruihao Zhou, Muqing Cao, Yizheng Tan*, Mark Neisser*, Huaping Xu* Sci. Adv.; 2025, 11, eadx1918 Extreme ultraviolet (EUV) lithography has become the essence of advanced semiconductor manufacturing processes. While enabling smaller feature sizes, EUV lithography imposes increasingly stringent requirements on the comprehensive performance and stochastic defect suppression of photoresist. The widely recognized strategy to minimize these defects is a material that integrates high EUV absorption and energy utilization into a homogeneous system based on molecular building blocks—the ideal formul...