Yizheng Tan, Yiheng Dai, Peng Zhao, Cheng Liu*, Huaping Xu* Matter; 2024, 7, 1117. Modular strategy is specialized in universality, compatibility, and simplicity. Although previous strategies still rely on highly customized processes, our research uses modular design to improve the simplicity and compatibility of shape programming. The module we used has a predefined hexagonal shape, which is mass-producible and can be transferred to a 2D substrate to produce controllable deformation in situ through nonpattern stimuli. This process can be finished in seconds due to the great responsiveness...

Chaowei He, Cheng Liu, Shuojiong Pan, Yizheng Tan, Jun Guan*, Huaping Xu* Angew. Chem. Int. Ed.; 2024, 68, e202317558. Degradable polymers offer a promising solution to mitigate global plastic pollution, but the degraded products often suffer from diminished value. Upcycling is a more sustainable approach to upgrade polymer waste into value-added products. Herein, we report a β-selenocarbonyl-containing polyurethane (SePU), which can be directly degraded under mild conditions into valuable selenium fertilizers for selenium-rich vegetable cultivation globally, enabling both plastic degradatio...

Banruo Xianyu, Shuojiong Pan, Shiqian Gao, Huaping Xu*, Tianyu Li* Small, 2023, 2306225. The blockade of immune checkpoints has emerged as a promising strategy for cancer immunotherapy. However, most of the current approaches focus on T cells, leaving natural killer (NK) cell-mediated therapeutic strategies rarely explored. Here, a selenium-containing nanocomplex is developed that acts as a dual immune checkpoint inhibitor to reinvigorate NK cell-based cancer immunotherapy. The Se nanocomplex can deliver and release siRNA that targets programmed death ligand-1 (PD-L1) in tumor cells, there...

Yizheng Tan, Jun Guan, Huaping Xu* Matter; 2023, 6, 3121. A hyper-stable cholesteric heliconical superstructure has been achieved at room temperature through a simple strategy of mixing liquid crystal dimers. This breakthrough, recently reported in Matter by Li and colleagues, demonstrates an unprecedented and practical optic system for monochromatic light filtering important for various fields.

Ningyue Chen, Shuwei Li, Peng Zhao, Ran Liu, Yu Xie, Jin-Liang Lin, Christian A. Nijhuis, Bingqian Xu, Liang Zhang*, Huaping Xu*, Yuan Li* Sci. Adv.; 2023, 9, eadh3412. The molecular electronic devices based on self-assembled monolayer (SAM) on metal surfaces demonstrate novel electronic functions for device minimization yet are unable to realize in practical applications, due to their instability against oxidation of the sulfur-metal bond. This paper describes an alternative to the thiolate anchoring group to form stable SAMs on gold by selenides anchoring group. Because of the formation of...

Bing Bai, Shaolong Qi, Kai Yang, Xinyang Yu, Ruijun Jian, Tianfang Zhang, Daming Wang, Hongbo Meng, Yifan Zhao, Yu Xia*, Huaping Xu*, Guocan Yu*, Zuobing Chen* Small; 2023, 19, 2300217. Hepatic ischemia-reperfusion injury (HIRI) is a critical complication after liver surgery that negatively affects surgical outcomes of patients with the end-stage liver-related disease. Reactive oxygen species (ROS) are responsible for the development of ischemia-reperfusion injury and eventually lead to hepatic dysfunction. Selenium-doped carbon quantum dots (Se-CQDs) with an excellent redox-responsive pro...

Yiheng Dai, Zhiheng Zhang, Mathias Daniels, Yu Bao, Jun Guan, Shenghan Zhang, Ruihao Zhou, Yizheng Tan, Lichen Liu, Hai Xiao, Shuxun Cui, Huaping Xu* Chem; 2023, 9, 2006. In contrast to other main group elements, group VI elements are rarely observed to form long linear polymer main chains. We reported the synthesis and characterizations of polytelluoxane, a polymer with an inorganic main chain that constitutes tellurium and oxygen, which may bridge the gap between inorganic oxides and macromolecules. Polytelluoxane has a flexible Te–O backbone and can be facilely synthesized and further p...

Chengfei Liu, Banruo Xianyu, Yiheng Dai, Shuojiong Pan, Tianyu Li, and Huaping Xu* ACS Nano; 2023, 17, 11905. Polymerization inside living cells provides chemists with a multitude of possibilities to modulate cell activities. Considering the advantages of hyperbranched polymers, such as a large surface area for target sites and multilevel branched structures for resistance to the efflux effect, we reported a hyperbranched polymerization in living cells based on the oxidative polymerization of organotellurides and intracellular redox environment. The intracellular hyperbranched polymerizati...

Yiheng Dai, Jun Guan, Shenghan Zhang, Shuojiong Pan, Banruo Xianyu, Zhuoxin Ge, Jinyan Si, Chaowei He, Huaping Xu Prog. Polym. Sci.; 2023, 141, 101678. Significant progresses have been made in tellurium-containing polymers over the past decades. Just like other heteroatom-containing polymers, tellurium-containing polymers exhibit several unique properties and promising applications. However, unlike elements such as boron, silicon, sulfur and so on, tellurium in polymers remains a fresh perspective for many researchers. In this review, we shall illustrate the diversification of tellurium-...

Shuojiong Pan, Jun Guan, Banruo Xianyu, Yizheng Tan, Tianyu Li, and Huaping Xu Adv. Mater.; 2023, 23, 2211370. As a specialized immune effector cell, natural killer (NK) cells play a very important role in immunotherapy, but tumor immunosuppression caused by abnormal expression of cancer cells seriously weakens its therapeutic effect and leads to exhaustion. Here, we developed a self-assembled selenium containing nanoparticles (NPs) composed of Cetuximab, C5SeSeC5 and inhibitor LY345899 to reverse NK cell exhaustion. The obtained NPs can target EGFR on the surface of cancer cells and locat...