Jichun Yang, Shuojiong Pan, Shiqian Gao, Yiheng Dai, Huaping Xu Biomaterials; 2020, 249, 120054. Thioredoxin reductase (TrxR) is an essential mammalian enzyme that possesses a selenocysteine active site. TrxR is overexpressed in many malignant tumors and has a close relationship with apoptosis, drug resistance, recurrence and metastasis of tumors. Recently, TrxR has emerged as a promising target for anticancer therapy. Herein, we developed a TrxR-interfering drug delivery system (DDS) based on RGD-PEG-PUSeSe-PEG-RGD self-assembling micelles for imaging-guided gemcitabine (GEM) chemosensiti...

Yiheng Dai, Ke Zheng, Yizheng Tan, Wentian Xiang, Banruo Xianyu, Huaping Xu Adv. Sustainable Syst.; 2020, 4, 2000072. Faced with ever-severe gold mineral depletion, it is meaningful to obtain a sustainable gold resource by utilization of accumulating waste electrical and electronic equipment (WEEE). Inspired by fischesserite, the first naturally occurring selenide of gold, a novel selenium-containing polyurethane (Se-polyurethane) is prepared. This material is able to extract aqueous gold in its elemental form with a selectivity 437 times over Cu and 443 times over Ni and a capacity of 802...

Shuojiong Pan, Jichun Yang, Shaobo Ji, Tianyu Li, Shiqian Gao, Chenxing Sun, Huaping Xu CCS Chem.; 2020, 2, 225–235. Thioredoxin Reductase (TrxR) plays a pivotal role in defending cells against reactive oxygen species (ROS) and maintaining a reduced intracellular environment. It has been discovered that TrxR is elevated significantly in human cancer, evidenced by its association with the promotion of tumor cell proliferation, inhibiting tumor cell apoptosis, as well as enhancing tumor drug resistance. Hence, finding highly selective inhibitors of TrxR is urgently needed. Herein, we develo...