Peng Zhao, Jiahao Xia, Muqing Cao, Huaping Xu ACS Macro Lett., 2020, 9, 163-168. Wavelength-controlled Se–S dynamic chemistry was put forward recently as a convenient way to regulate the balance of a selenide sulfide exchange reaction. In this paper, we synthesized an asymmetric polymeric amphiphile linked with a Se–S bond and then induced it to self-assemble into vesicles in water. When the visible light was applied to the assembly solution with addition of toluene, Se–S bonds containing vesicles were ruptured. Thus, the wavelength-controlled light responses of relatively stable polymer a...

Tianyu Li, Shuojiong Pan, Shiqian Gao, Wentian Xiang, Chenxing Sun, Wei Cao, Huaping Xu Angew. Chem. Int. Ed., 2020, 59, 2700-2704. Immunotherapy has emerged as a promising new approach for cancer treatment. However, clinically available drugs have been limited until recently, and the antitumor efficacy of most cancer immunotherapies still needs to be improved. Herein, we develop diselenide-pemetrexed assemblies that combine nature killer (NK) cell-based cancer immunotherapy with radiotherapy and chemotherapy in a single system. The assemblies are prepared via co-assembly between pemetre...

Jiahao Xia, Hongbin Li, Huaping Xu Acta Polym. Sin., 2020, 51, 205. Sulfur, selenium-containing bonds, including disufide bond (SS), diselenide bond (SeSe) and selenide-sulfide bond (SeS), are an important type of light responsive dynamic covalent bonds. Among them SS and SeS bond can undergo exchange reaction with the irridiation of UV light while SeSe bond only requires visible light. In this paper we prepared SS or SeSe bond modified quartz substrate via surface modification. Based on the light induced exchange reaction we can obtain polymer chain attached substrates linked by a singl...

Chenxing Sun, Lu Wang, Banruo Xianyu, Tianyu Li, Shiqian Gao, Huaping Xu Biomaterials, 2019, 225, 119514. Selenoxide elimination reaction has been widely used in the field of organic synthesis. However, few studies have been conducted to apply this reaction in biodegradable nanomedicine. In this work, the selenoxide elimination reaction was used for cancer treatment via producing excess cellular reactive oxygen species (ROS) for the first time. The β-seleno diesters and porphyrin derivates containing nanoparticle could be responsive to the intracellular ROS and produce acrylates through ...

Wei Cao, Huaping Xu Mater. Chem. Front., 2019, 3, 2010-2017. Supra-amphiphiles formed by noncovalent interactions are a versatile bottom-up fabrication strategy for functional soft materials. Selenium chemistry possesses many unique properties and selenium-containing polymers made by covalent synthesis have developed enormously in the past few decades. Supra-amphiphiles built on selenium-containing species offer more opportunities for functional systems without too many synthetic efforts. This review will give a brief overview of different types of selenium-containing supra-amphiphiles b...