Measuring the Strength of S/Se Based Dynamic Covalent Bonds

Jiahao Xia, Hongbin Li, Huaping Xu Acta Polym. Sin., 2020, 51, 205. Sulfur, selenium-containing bonds, including disufide bond (SS), diselenide bond (SeSe) and selenide-sulfide bond (SeS), are an important type of light responsive dynamic covalent bonds. Among them SS and SeS bond can undergo exchange reaction with the irridiation of UV light while SeSe bond only requires visible light. In this paper we prepared SS or SeSe bond modified quartz substrate via surface modification. Based on the light induced exchange reaction we can obtain polymer chain attached substrates linked by a singl...
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Selenoxide Elimination Manipulate the Oxidative Stress to Improve the Antitumor Efficacy

Chenxing Sun, Lu Wang, Banruo Xianyu, Tianyu Li, Shiqian Gao, Huaping Xu Biomaterials, 2019, 225, 119514. Selenoxide elimination reaction has been widely used in the field of organic synthesis. However, few studies have been conducted to apply this reaction in biodegradable nanomedicine. In this work, the selenoxide elimination reaction was used for cancer treatment via producing excess cellular reactive oxygen species (ROS) for the first time. The β-seleno diesters and porphyrin derivates containing nanoparticle could be responsive to the intracellular ROS and produce acrylates through ...
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Selenium-Containing Supra-Amphiphiles

Wei Cao, Huaping Xu Mater. Chem. Front., 2019, 3, 2010-2017. Supra-amphiphiles formed by noncovalent interactions are a versatile bottom-up fabrication strategy for functional soft materials. Selenium chemistry possesses many unique properties and selenium-containing polymers made by covalent synthesis have developed enormously in the past few decades. Supra-amphiphiles built on selenium-containing species offer more opportunities for functional systems without too many synthetic efforts. This review will give a brief overview of different types of selenium-containing supra-amphiphiles b...
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Swelling-Induced 3D Photopatterning on a Diselenide-Containing Elastomer

Fuqiang Fan, Cheng Liu, Sha Wang, Jinqiu Lv, Wenze Li, Yu Fu, Huaping Xu J. Mater. Chem. C, 2019, 7, 10777-10782. An ordered pattern or a distinct texture on surfaces endows materials with specific applications, such as oil-water separation, advanced anticounterfeiting and optical devices. Conventional photolithography and surface patterning methods can form only 2D patterns, and they are also limited by the shape of a material and the required equipment. In this study, a swelling-induced 3D photopatterning (SPP) method is demonstrated to manipulate both the shape and surface pattern of a ...
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Recent Progress in the Biological Applications of Reactive Oxygen Species-Responsive Polymers

Zhiyuan Fan, Huaping Xu Polym. Rev., 2020, 60, 114-143. Responsive polymeric materials that are sensitive to biological stimuli including temperature, pH, enzymes, or redox conditions have attracted research interest in recent years. Among these, reactive oxygen species (ROS)-responsive polymers are particularly appealing because of the special role of ROS in living organisms. ROS are the indicator and cause of certain diseases, and they are also important signaling molecules. ROS-responsive polymers could possess the following functions: drug carriers, ROS probes, or medications for cer...
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Congratulations to Ms. Lu Wang, Mr. Tianyu Li, Mr. Wentian Xiang and Mr. Ke Zheng on their graduation

毕业合照
Congratulations to Ms. Lu Wang and Mr. Tianyu Li on getting their PhD degrees! Congtatulations to Mr. Wentian Xiang on getting his master degree! Congratulations to Mr. Ke Zheng on getting his bachelor degree! Mr. Tianyu Li was honoured with "Outstanding PhD Thesis of Tsinghua University". Mr. Ke Zheng was honoured with "T. P. Hou AWARD", "Outstanding Bachelor Thesis of Tsinghua University" and "Outstanding Graduate Student of Beijing".
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Xu’s Group attended Tsinghua Univeristy Chemistry Department-Panjin Joint Doctoral Academic Forum Shimadzu Scholarship Thesis Review Conference

夏嘉豪口头报告一等奖
On May 10th — 12th 2019, Prof. Huaping Xu and Jiahao Xia and Chenxing Sun attended Tsinghua Univeristy Chemistry Department-Panjin Joint Doctoral Academic Forum Shimadzu Scholarship Thesis Review Conference held in Panjin, Liaoning. On May 11th, Prof. Huaping Xu chaired the academic reports. Jiahao Xia gave an oral presntation named "Diselenide Dynamic Chemistry at the Interface". Jiahao Xia and Chenxing Sun gave poster presentations, respectively. Jiahao Xia was honoured with "Best Oral Presentation Award". Chenxing Sun was honoured with "Best Poster Presentation Award". &n...
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