Tianyu Li, Shuojiong Pan, Shiqian Gao, Wentian Xiang, Chenxing Sun, Wei Cao, Huaping Xu
Angew. Chem. Int. Ed., 2020, 59, 2700-2704.
Immunotherapy has emerged as a promising new approach for cancer treatment. However, clinically available drugs have been limited until recently, and the antitumor efficacy of most cancer immunotherapies still needs to be improved. Herein, we develop diselenide-pemetrexed assemblies that combine nature killer (NK) cell-based cancer immunotherapy with radiotherapy and chemotherapy in a single system. The assemblies are prepared via co-assembly between pemetre...
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Author: wanglu
Congratulations! PhD student Jiahao Xia received “Best Poster Award” in 2019 the 16th Pacific Polymer Conference
Jiahao Xia presented a poster presentation of “Diselenide Dynamic Chemistry at the Interface” on the 16th Pacific Polymer Conference held in Singapore from Dec.8th to Dec.12th, 2019. He got the “Best Poster Award” presented by the committee of Pacific Polymer Federation.
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The 2nd Table Tennis Match of Xu’s Group
On Sep. 27th, 2019, the 2nd Table Tennis Match of Xu's Group was held in Gas Film Hall, Tsinghua University.
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Measuring the Strength of S/Se Based Dynamic Covalent Bonds
Jiahao Xia, Hongbin Li, Huaping Xu
Acta Polym. Sin., 2020, 51, 205.
Sulfur, selenium-containing bonds, including disufide bond (SS), diselenide bond (SeSe) and selenide-sulfide bond (SeS), are an important type of light responsive dynamic covalent bonds. Among them SS and SeS bond can undergo exchange reaction with the irridiation of UV light while SeSe bond only requires visible light. In this paper we prepared SS or SeSe bond modified quartz substrate via surface modification. Based on the light induced exchange reaction we can obtain polymer chain attached substrates linked by a singl...
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Selenoxide Elimination Manipulate the Oxidative Stress to Improve the Antitumor Efficacy
Chenxing Sun, Lu Wang, Banruo Xianyu, Tianyu Li, Shiqian Gao, Huaping Xu
Biomaterials, 2019, 225, 119514.
Selenoxide elimination reaction has been widely used in the field of organic synthesis. However, few studies have been conducted to apply this reaction in biodegradable nanomedicine. In this work, the selenoxide elimination reaction was used for cancer treatment via producing excess cellular reactive oxygen species (ROS) for the first time. The β-seleno diesters and porphyrin derivates containing nanoparticle could be responsive to the intracellular ROS and produce acrylates through ...
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Selenium-Containing Supra-Amphiphiles
Wei Cao, Huaping Xu
Mater. Chem. Front., 2019, 3, 2010-2017.
Supra-amphiphiles formed by noncovalent interactions are a versatile bottom-up fabrication strategy for functional soft materials. Selenium chemistry possesses many unique properties and selenium-containing polymers made by covalent synthesis have developed enormously in the past few decades. Supra-amphiphiles built on selenium-containing species offer more opportunities for functional systems without too many synthetic efforts. This review will give a brief overview of different types of selenium-containing supra-amphiphiles b...
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Swelling-Induced 3D Photopatterning on a Diselenide-Containing Elastomer
Fuqiang Fan, Cheng Liu, Sha Wang, Jinqiu Lv, Wenze Li, Yu Fu, Huaping Xu
J. Mater. Chem. C, 2019, 7, 10777-10782.
An ordered pattern or a distinct texture on surfaces endows materials with specific applications, such as oil-water separation, advanced anticounterfeiting and optical devices. Conventional photolithography and surface patterning methods can form only 2D patterns, and they are also limited by the shape of a material and the required equipment. In this study, a swelling-induced 3D photopatterning (SPP) method is demonstrated to manipulate both the shape and surface pattern of a ...
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Recent Progress in the Biological Applications of Reactive Oxygen Species-Responsive Polymers
Zhiyuan Fan, Huaping Xu
Polym. Rev., 2020, 60, 114-143.
Responsive polymeric materials that are sensitive to biological stimuli including temperature, pH, enzymes, or redox conditions have attracted research interest in recent years. Among these, reactive oxygen species (ROS)-responsive polymers are particularly appealing because of the special role of ROS in living organisms. ROS are the indicator and cause of certain diseases, and they are also important signaling molecules. ROS-responsive polymers could possess the following functions: drug carriers, ROS probes, or medications for cer...
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Congratulations to Ms. Lu Wang, Mr. Tianyu Li, Mr. Wentian Xiang and Mr. Ke Zheng on their graduation
Congratulations to Ms. Lu Wang and Mr. Tianyu Li on getting their PhD degrees!
Congtatulations to Mr. Wentian Xiang on getting his master degree!
Congratulations to Mr. Ke Zheng on getting his bachelor degree!
Mr. Tianyu Li was honoured with "Outstanding PhD Thesis of Tsinghua University".
Mr. Ke Zheng was honoured with "T. P. Hou AWARD", "Outstanding Bachelor Thesis of Tsinghua University" and "Outstanding Graduate Student of Beijing".
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Ms. Lu Wang, Mr. Tianyu Li and Mr. Wentian Xiang passed their graduate dissertation defenses
On May 22nd, Ms. Lu Wang and Mr. Tianyu Li passed their Ph.D. dissertation defenses.
On May 30rd, Mr. Wentian Xiang passed his master dissertation defense.
Congratulations to Lu, Tianyu and Wentian!
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