Shiqian Gao, Tianyu Li, Ye Guo, Chenxing Sun, Banruo Xianyu, Huaping Xu Adv. Mater.; 2020, 32, 1907568. Considering the limited clinical benefits of individual approaches against malignancy, natural killer (NK) cell-mediated immunotherapy is increasingly utilized in combination with radiotherapy and target therapeutics. However, the interplay of targeted agents, immunotherapy and radiotherapy is complex. An improved understanding of the effect of chemotherapy or radiotherapy on specific molecular pathways in immune cells would help to optimize the synergistic anti-tumour efficiency. In thi...

Cheng Liu, Zhiyuan Fan, Yizheng Tan, Fuqiang Fan, Huaping Xu Adv. Mater.; 2020, 32, 1907569. Structural color materials with reversible stimuli-responsiveness to external environment have been widely used in sensors, encryption, display and other fields. Compared with other stimuli, visible light is highly controllable both temporally and spatially with less damage to materials, which is more suitable for structural color patterning. Herein, a new diselenide-containing shape memory material is prepared and used for creating patterns via visible light stimulus. In this system, the structura...

Tianyu Li, Shuojiong Pan, Hao Zhuang, Shiqian Gao, Huaping Xu ACS Appl. Bio Mater., 2020, 3, 1283-1292. Developing multifunctional carrier-free nanomedicine with high efficacy attracts tremendous attention in cancer treatment. Here, we develop selenium-containing carrier-free assemblies with aggregation-induced emission (AIE) property, which achieve the combination of cancer radiotherapy with chemotherapy. Under γ-radiation, diselenide bonds in the assemblies can be cleaved to form seleninic acid, which exhibits anticancer activity by upregulating the reactive oxygen species (ROS) levels i...

Peng Zhao, Jiahao Xia, Muqing Cao, Huaping Xu ACS Macro Lett., 2020, 9, 163-168. Wavelength-controlled Se–S dynamic chemistry was put forward recently as a convenient way to regulate the balance of a selenide sulfide exchange reaction. In this paper, we synthesized an asymmetric polymeric amphiphile linked with a Se–S bond and then induced it to self-assemble into vesicles in water. When the visible light was applied to the assembly solution with addition of toluene, Se–S bonds containing vesicles were ruptured. Thus, the wavelength-controlled light responses of relatively stable polymer a...

Tianyu Li, Shuojiong Pan, Shiqian Gao, Wentian Xiang, Chenxing Sun, Wei Cao, Huaping Xu Angew. Chem. Int. Ed., 2020, 59, 2700-2704. Immunotherapy has emerged as a promising new approach for cancer treatment. However, clinically available drugs have been limited until recently, and the antitumor efficacy of most cancer immunotherapies still needs to be improved. Herein, we develop diselenide-pemetrexed assemblies that combine nature killer (NK) cell-based cancer immunotherapy with radiotherapy and chemotherapy in a single system. The assemblies are prepared via co-assembly between pemetre...