Selenium–Platinum Coordination Dendrimers with Controlled Anti-Cancer Activity

Tianyu Li, Mario Smet, Wim Dehaen, and Huaping Xu ACS Appl. Mater. Interfaces, 2016, 8, 3609-3614. Dendrimers are considered as good vectors for drug delivery in cancer treatment. However, most anticancer drugs are conjugated to the peripheral surface of dendrimers, sacrificing the advantages of monodispersity and stability belonging to dendrimers. Furthermore, dendrimers in current studies of cancer treatment are mostly used as vectors for drugs, whereas the anticancer activity of dendrimers on their own is less studied. Here we have prepared monodisperse selenium–platinum coordination ...
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Visible-Light-Induced Self-Healing Diselenide-Containing Polyurethane Elastomer

Shaobo Ji, Wei Cao, Ying Yu and Huaping Xu Adv. Mater., 2015, 27, 7740-7745. Visible light is an easily achievable and mild trigger for self-healing materials. By incorporating dynamic diselenide bonds into polyurethane, visible-light-induced self-healing materials can be fabricated. Besides mild visible light, the healing process can also be realized using directional laser irradiation, which makes the system a remotely controllable self-healing system.
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Sun, Xiang and Chen finished Summer Internship

Summer intern
Three undergraduate students of our group, Wentian Xiang, Ruofan Chen and Chenxing Sun, went to different groups as exchange students in this summer vacation. Xiang worked on “DNA-coated colloids (Fluorinated latex particles and gold nanoparticles)” in Oren Scherman’s group in Cambridge. Chen and Sun went to UCSD and studied in Adah Almutairi’s and Liangfang Zhang’s group respectively. Their research projects were “pH- and ROS-responsive polymer” and “cell membrane coated nanofiber”. This Program was supported by Tsinghua Xuetang Program. Picture 1. Chen and Sun went to San Diego Z...
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Ultra-sensitive ROS-responsive Coassemblies of Tellurium-Containing Molecules and Phospholipids

Lu Wang, Fuqiang Fan, Wei Cao and Huaping Xu ACS Appl. Mater. Interfaces, 2015, 7, 16054-16060. Reactive oxygen species (ROS) play a crucial role in cell signaling and redox homeostasis and are strongly related to metabolic activities. The increase of ROS concentration in organisms can result in several diseases, such as cardiovascular diseases and cancer. The concentration of ROS in biologically-relevant conditions is typically as low as around tens of μM to 100 μM H2O2, which makes it necessary to develop ultra-sensitive ROS-responsive systems. A general approach is reported here to fa...
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Mr. Wei Cao participated in the 65th Lindau Nobel Laureate Meeting

lindau Wei Cao
Mr. Wei Cao participated in the 65th Lindau Nobel Laureate Meeting, Lindau, Germany as young scientists from June 28 th to July 3 rd, 2015. He was selected as a speaker for the Nobel laureate Prof. Jean-Marie Lehn’s master class on “Supramolecular and Adaptive Chemistry: From Materials Science to Medicine”. The delegation of China was made up of 30 Ph.D. candidates all over the country of different backgrounds including physiology and medicine, chemistry, and physics. After the Lindau Nobel Laureate Meeting, they had a scientific trip around Germany and visited some of the important universiti...
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