Shenghan Zhang, Yijie Lu, Junjie Song, Jun Guan, Yiheng Dai, Wei Cao*, and Huaping Xu* Angew. Chem. Int. Ed.; 2025, e202415811 Regulating chemical drug's responsiveness to gamma radiation is crucial for achieving better therapeutic effects in cancer treatment. Most research focused on thermodynamic chemical structure design, while little attention was paid to kinetic regulate strategy, which possesses greater universality and security. In this study, we achieved a kinetic-based regulate strategy of gamma radiation reaction, through the construction of microphase environment during polymeri...

Chengfei Liu, Banruo Xianyu, Chaowei He, Muqing Cao, Zhuolin Chen, Tianyu Li and Huaping Xu* CCS Chem.; 2025, 403-415 Topological polymers play a major role in their interaction with intracellular organelles to affect their cellular activities owing to their large surface area and multilevel branched structures. Yet, the existing studies on these polymers mainly focus on the topochemical polymerization outside the cells and how these topological polymers interact with the cell outer membrane. Herein, we established an intracellular topological polymerization based on the 2′-Te modified o...

Mengnan Liu1, Fanqiang Bu1, Guofeng Li, Wensheng Xie, Huaping Xu*, Xing Wang* The Innovation Life.; 2024, 2, 100076 The hydrogen sulfide (H2S)-induced defense system is a crucial bacterial pathway that leads to antibiotic resistance. Herein, a unique S-Se-S molecule, namely, 2,2’-(selenobis(sulfanediyl))diacetic acid (Se-Acid), is first reported to relieve H2S-induced antibiotic resistance by acting as a hydrogen selenide (H2Se) donor. The S-Se-S molecular structure was formed using the carboxyl terminal as an electron acceptor. After being endocytosed by cells, Se-Acid effectively released ...

Xiuji Du, Yongzheng Xing, Yujie Li, Muqing Cao, Jun Wu, Guizhi Dong, Ziwei Shi, Xunan Wei, Miaomiao Qiu, Junjie Gao, Yun Xu, Huaping Xu, Dongsheng Liu, Yuanchen Dong* Macromol. Rapid Commun.; 2024, 45, 2400177 The dynamic mechanical strength of the extracellular matrix (ECM) has been demonstrated to play important role in determining the cell behavior. Growing evidences suggest that the gradual stiffening process of the matrix is particularly decisive during tissue development and wound healing. Herein, a novel strategy to prepare hydrogels with gradually enhanced mechanical strength is prov...

Yizheng Tan, Yiheng Dai, Peng Zhao, Cheng Liu*, Huaping Xu* Matter; 2024, 7, 1117. Modular strategy is specialized in universality, compatibility, and simplicity. Although previous strategies still rely on highly customized processes, our research uses modular design to improve the simplicity and compatibility of shape programming. The module we used has a predefined hexagonal shape, which is mass-producible and can be transferred to a 2D substrate to produce controllable deformation in situ through nonpattern stimuli. This process can be finished in seconds due to the great responsiveness...

Chaowei He, Cheng Liu, Shuojiong Pan, Yizheng Tan, Jun Guan*, Huaping Xu* Angew. Chem. Int. Ed.; 2024, 68, e202317558. Degradable polymers offer a promising solution to mitigate global plastic pollution, but the degraded products often suffer from diminished value. Upcycling is a more sustainable approach to upgrade polymer waste into value-added products. Herein, we report a β-selenocarbonyl-containing polyurethane (SePU), which can be directly degraded under mild conditions into valuable selenium fertilizers for selenium-rich vegetable cultivation globally, enabling both plastic degradatio...