Jichun Yang, Shuojiong Pan, Shiqian Gao, Tianyu Li, Huaping Xu Biomaterials, 271, 120721. Carbon monoxide (CO) therapy and antiangiogenesis therapy (AAT) are regarded as promising approaches for cancer treatment. However, the poor tumor targeting ability and inevitable side effects prevent their clinical application. In this study, we developed H2O2-responsive diselenide-containing micelles that combined CO therapy with chemosensitization therapy and AAT in a single system. Under the interaction of intratumoral H2O2, CO and gemcitabine (GEM) were released in situ from the micelles to redu...

Cheng Liu, Zhiheng Zhang, Zhiyuan Fan, Chaowei He, Yizheng Tan, Huaping Xu Chem. Asian J.; 2020, 15, 4321. Regulating the reactivity and equilibrium of dynamic reaction is essential for adaptive chemistry and functional materials. Herein, cucurbituril-based host-guest interaction was embedded into the dynamic metathesis between diselenide and ditelluride to establish an equilibrium-adaptive system. In this system, cucurbit[6]uril (CB[6]) selectively bound with diselenide while cucurbit[7]uril (CB[7]) bound with not only diselenide but also ditelluride and exchange product. The dynamic natu...

Peng Zhao, Cong-Qiao Xu, Chenxing Sun, Jiahao Xia, Lin Sun, Jun Li and Huaping Xu Polym. Chem.; 2020, 11, 7087. Silver(I)–chalcogenide interactions have been widely found in the mineral paragenesis and are of great significance in medicinal systems. An accurate understanding of the intrinsic nature of these interactions would provide the basis for comprehending the involved natural and biological behaviors. However, few systematic works exploring the relative strength of silver(I)–chalcogenide bonds had been reported before. Thus, by combining single-molecule force spectroscopy (SMFS) from...

Jiahao Xia, Yizheng Tan, Huaping Xu Acta Polym. Sin.; 2020, 51, 1190. The dynamic covalent bond (DCB) is a kind of special bond that can cleave, reform, and exchange under external stimulus. DCBs have been evolved in a wide range of polymers like self-healing materials, shape memory materials and so on. Selenium is an essential element in human bodies. Our research group pioneered in the research of Se-containing dynamic polymers, and discovered that many Se-containing bonds are dynamic covalent bonds with very mild responsive conditions due to selenium’s unique chemical properties. This f...

Chenxing Sun, Yizheng Tan, Huaping Xu ACS Materials Lett.; 2020, 2, 1173. Nanomaterials are good platforms for the combination of different cancer treatments, such as radiotherapy, chemotherapy, and immunotherapy. However, those materials mostly serve as delivery vehicles for efficient and targeted transport of anticancer drugs. Stimuli-responsive chemical bonds have already been widely applied to construct these nanomaterials for controlled drug release. Diselenide bonds are one example of dual redox responsive bonds. Different from other stimuli-responsive nanomaterials, diselenide- c...

Tianyu Li, Huaping Xu Cell Rep. Phys. Sci.; 2020, 1, 100111. Cancer remains a major global health problem, causing significant economic burden worldwide. Current clinical cancer treatments are unsatisfactory in terms of both antitumor efficacy and biocompatibility. Meanwhile, nanomaterials attract much attention as potential treatment strategies with improved antitumor efficacy and reduced side effects. Selenium-containing nanomaterials are considered to be a promising biomaterial candidate among many different approaches during the last decade. Selenium-containing nanomaterials exhibit go...