Tuning Polymeric Amphiphilicity via Se-N Interactions: towards One-step Double Emulsion for Highly Selective Enzyme Mimics

Xiaopeng Huang, Ruochen Fang, Dingguan Wang, Jian Wang, Huaping Xu, Yapei Wang and Xi Zhang Small, 2015, 11, 1537-1541. A selenium-containing small molecule is exploited to controllably tune the polymer amphiphilicity, leading to fabrication of appropriate polymer surfactants through which one-step double emulsions can be obtained in a facile, scalable, surfactant-free approach. After solvent evaporation, these resulting porous microparticles are shown to be the exceptional artificial GPx enzyme mimics.  
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Dual Redox Responsive Coassemblies of Diselenide-Containing Block Copolymers and Polymer Lipids

Lu Wang, Wei Cao, Yu Yi, and Huaping Xu Langmuir, 2014, 30, 5628-5636. A general approach is reported to fabricate a stimuli responsive system via coassembly of diselenide-containing block copolymers with polymer lipids, which integrates the stimuli-responsiveness of diselenide chemistry and the biocompatibility of polymer lipids. By using dynamic light scattering, transmission electron microscopy, and zeta potential analyzer, coassembly behavior of these two kinds of polymers and responsiveness of coassemblies have been investigated. These coassemblies can exhibit redox-responsiveness i...
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