Chenxing Sun, Shiqian Gao, Yizheng Tan, Zhiheng Zhang, and Huaping Xu ACS Biomater. Sci. Eng., 2021, 7, 3201. The abnormal tumor vasculature in solid tumors creates hypoxia and leads to compromising the delivery and anticancer efficiency of nanomedicine. Nanomaterials with intrinsic antiangiogenesis ability might normalize tumor vessels and improve the therapeutic effect of O2-related treatment like PDT. Herein, we designed and prepared ROS-responsive side-chain selenium-grafted polymers, which had potential antiangiogenic activity, as vehicles to load photodynamic therapeutic agent Ce6 an...

Qiaomei Chen, Yang Yang, Ying Yu, and Huaping Xu J. Chem. Educ.; 2021, 98, 1429. This article introduces a novel experiment that involves vitrimers, a new type of polymer, in polymer chemistry and physics lab courses for undergraduate students. Vitrimers are permanently cross-linked networks that can be reprocessed under certain external stimuli. Therefore, they combine the advantages of traditional thermoplastics (excellent reprocessability) with thermosets (outstanding mechanical properties and environmental stability). They can be regarded as a kind of “special thermoset”, which moves t...

Jichun Yang, Shuojiong Pan, Shiqian Gao, Tianyu Li, Huaping Xu Biomaterials, 271, 120721. Carbon monoxide (CO) therapy and antiangiogenesis therapy (AAT) are regarded as promising approaches for cancer treatment. However, the poor tumor targeting ability and inevitable side effects prevent their clinical application. In this study, we developed H2O2-responsive diselenide-containing micelles that combined CO therapy with chemosensitization therapy and AAT in a single system. Under the interaction of intratumoral H2O2, CO and gemcitabine (GEM) were released in situ from the micelles to redu...

Cheng Liu, Zhiheng Zhang, Zhiyuan Fan, Chaowei He, Yizheng Tan, Huaping Xu Chem. Asian J.; 2020, 15, 4321. Regulating the reactivity and equilibrium of dynamic reaction is essential for adaptive chemistry and functional materials. Herein, cucurbituril-based host-guest interaction was embedded into the dynamic metathesis between diselenide and ditelluride to establish an equilibrium-adaptive system. In this system, cucurbit[6]uril (CB[6]) selectively bound with diselenide while cucurbit[7]uril (CB[7]) bound with not only diselenide but also ditelluride and exchange product. The dynamic natu...

Peng Zhao, Cong-Qiao Xu, Chenxing Sun, Jiahao Xia, Lin Sun, Jun Li and Huaping Xu Polym. Chem.; 2020, 11, 7087. Silver(I)–chalcogenide interactions have been widely found in the mineral paragenesis and are of great significance in medicinal systems. An accurate understanding of the intrinsic nature of these interactions would provide the basis for comprehending the involved natural and biological behaviors. However, few systematic works exploring the relative strength of silver(I)–chalcogenide bonds had been reported before. Thus, by combining single-molecule force spectroscopy (SMFS) from...

Jiahao Xia, Yizheng Tan, Huaping Xu Acta Polym. Sin.; 2020, 51, 1190. The dynamic covalent bond (DCB) is a kind of special bond that can cleave, reform, and exchange under external stimulus. DCBs have been evolved in a wide range of polymers like self-healing materials, shape memory materials and so on. Selenium is an essential element in human bodies. Our research group pioneered in the research of Se-containing dynamic polymers, and discovered that many Se-containing bonds are dynamic covalent bonds with very mild responsive conditions due to selenium’s unique chemical properties. This f...

Chenxing Sun, Yizheng Tan, Huaping Xu ACS Materials Lett.; 2020, 2, 1173. Nanomaterials are good platforms for the combination of different cancer treatments, such as radiotherapy, chemotherapy, and immunotherapy. However, those materials mostly serve as delivery vehicles for efficient and targeted transport of anticancer drugs. Stimuli-responsive chemical bonds have already been widely applied to construct these nanomaterials for controlled drug release. Diselenide bonds are one example of dual redox responsive bonds. Different from other stimuli-responsive nanomaterials, diselenide- c...

Tianyu Li, Huaping Xu Cell Rep. Phys. Sci.; 2020, 1, 100111. Cancer remains a major global health problem, causing significant economic burden worldwide. Current clinical cancer treatments are unsatisfactory in terms of both antitumor efficacy and biocompatibility. Meanwhile, nanomaterials attract much attention as potential treatment strategies with improved antitumor efficacy and reduced side effects. Selenium-containing nanomaterials are considered to be a promising biomaterial candidate among many different approaches during the last decade. Selenium-containing nanomaterials exhibit go...

Jichun Yang, Shuojiong Pan, Shiqian Gao, Yiheng Dai, Huaping Xu Biomaterials; 2020, 249, 120054. Thioredoxin reductase (TrxR) is an essential mammalian enzyme that possesses a selenocysteine active site. TrxR is overexpressed in many malignant tumors and has a close relationship with apoptosis, drug resistance, recurrence and metastasis of tumors. Recently, TrxR has emerged as a promising target for anticancer therapy. Herein, we developed a TrxR-interfering drug delivery system (DDS) based on RGD-PEG-PUSeSe-PEG-RGD self-assembling micelles for imaging-guided gemcitabine (GEM) chemosensiti...

Yiheng Dai, Ke Zheng, Yizheng Tan, Wentian Xiang, Banruo Xianyu, Huaping Xu Adv. Sustainable Syst.; 2020, 4, 2000072. Faced with ever-severe gold mineral depletion, it is meaningful to obtain a sustainable gold resource by utilization of accumulating waste electrical and electronic equipment (WEEE). Inspired by fischesserite, the first naturally occurring selenide of gold, a novel selenium-containing polyurethane (Se-polyurethane) is prepared. This material is able to extract aqueous gold in its elemental form with a selectivity 437 times over Cu and 443 times over Ni and a capacity of 802...