Wei Cao, Yuwei Gu, Tianyu Li and Huaping Xu Chem. Commun., 2015, 51, 7069-7071. A novel tellurium-containing polymer micelle system is reported to be responsive to 100 μM H2O2 and can undergo a series of morphological changes. The polymer micelles also respond to 2 Gy gamma radiation, which is the exact dosage a patient receives one day for clinical radiation therapy.

Ruochen Fang, Huaping Xu, Wei Cao, Liulin Yang and Xi Zhang Polym. Chem., 2015, 6, 2817-2821. Materials responsive to reactive oxygen species (ROS) at a physiological level are of great significance in diagnostic and therapeutic applications. We have synthesized a water-soluble tellurium-containing hyperbranched polymer and demonstrated that it forms a kind of ROS-responsive aggregate. In aqueous environment, the polymer aggregates can swell under biologically relevant concentration of H2O2, which could be expected to find applications in fields such as elimination of excess ROS.

Wei Cao, Lu Wang and Huaping Xu Chem. Commun., 2015,  51, 5520-5522. A coordination-responsive tellurium containing film was fabricated for controlled release. The coordination chemistry between telluride molecules and cisplatin was utilized for the load of cisplatin, while competitive ligands for triggered release. This work could enrich the coordination responsive system and further tune the release kinetics of cisplatin.  

Jian Gao, Yiliu Liu, Huaping Xu, Zhiqiang Wang, and Xi Zhang Langmuir, 2009, 25, 4365-4369. In this letter, we present a very convenient and efficient technique of direct replication of biological structures via a two-step phase-separation micromolding process (PSμM). Our study has demonstrated that PSμM can be used to replicate the surface structure of a lotus leaf. On one hand, the micro/nanostructures of the lotus leaf are well replicated after a two-step PSμM. On the other hand, the replicated artificial lotus leaf shows good superhydrophobicity, similar to that of the natural lotus ...

Huaping Xu, Alberto Gomez-Casado, Zhihua Liu, David N. Reinhoudt, Rob G. H. Lammertink, and Jurriaan Huskens Langmuir, 2009, 25, 13972-13977. A polyelectrolyte multilayer was assembled on top of a patterned PDMS stamp employing the layer-by-layer (LbL) assembly technique. By post-treatment with a base and further cross-linking, a porous multilayer-coated PDMS composite stamp was obtained. With the pore structures acting as an ink reservoir, the multiple printing of proteins was successfully achieved without the need to re-ink the stamp.

Huaping Xu and Jurriaan Huskens Chem. Eur. J., 2010, 16, 2342-2348. Microcontact printing is a heavily used surface modification method in materials and life science applications. This concept article focuses on the development of versatile stamps for microcontact printing that can be used to bind and release inks through molecular recognition or through an ink reservoir, the latter being used for the transfer of heavy inks, such as biomolecules and particles. Conceptually, such stamp properties can be introduced at the stamp surface or by changing the bulk stamp material; both lines of ...

Ning Ma, Ying Li, Huaping Xu, Zhiqiang Wang, and Xi Zhang J. Am. Chem. Soc., 2010, 132, 442-443. A block copolymer with diselenide bonds in the polymer backbone was reported. This block copolymer was capable of forming micellar aggregates that were responsive to redox stimuli. Compared with other redox responsive aggregates, this type of diselenide-containing block copolymer aggregates could be responsive to both oxidants and reductants even in a solution with a very low concentration under mild conditions.

Jian Gao, Yiliu Liu, Huaping Xu, Zhiqiang Wang, and Xi Zhang Langmuir, 2010, 26, 9673–9676. We present a very efficient and convenient approach to obtain smart biosurfaces by directly replicating biological surface structures. It is realized by a two-step replication process combining regular replica molding and tempetature-induced phase separation micromolding (PSμM). The negative replicas of biological surface structures using poly(dimethylsiloxane) as the replication material are durable molds for further replication. The positive replicas of biological surface structures are obtained...

Zhihua Liu, Yu Yi, Huaping Xu, Xi Zhang, Thien Huynh Ngo, and Mario Smet Adv. Mater., 2010, 22, 2689-2693. Cation-selective microcontact printing (μCP) is achieved by the combination of a surface-molecular-imprinted layer-by-layer (SMILbL) films with μCP. The SMILbL film greatly enhances the charge selectivity of the imprinted-film-modified stamp and the PDMS stamp modified by the SMILbL film shows a high selectivity to multiply charged cations. The SMILbL-film-modified stamp can also be used for selective transfer of single-charged chemical species.

Ning Ma, Ying Li, Huifeng Ren, Huaping Xu, Zhibo Li, and Xi Zhang Polym. Chem., 2010, 1, 1609-1614. A selenium-containing amphiphilic block copolymer (PEG-PUSe-PEG) with a hydrophobic polyselenide block and two hydrophilic poly(ethylene glycol) (PEG) blocks was synthesized via polymerization of toluene diisocyanate (TDI) with monoselenide-containing diols and subsequent termination with PEG monomethylether. PEG-PUSe-PEG is able to self-assemble in aqueous solution to form block copolymer aggregates. Interestingly, it was found that the aggregates have a good oxidation-responsiveness and ...