Author: wanglu
Nanomedicine Assembled by Coordinated Selenium-Platinum Complexes Can Selectively Induce Cytotoxicity in Cancer Cells by Targeting the Glutathione Antioxidant Defense System
Feng Li, Tianyu Li, Xuexiang Han, Hao Zhuang, Guangjun Nie, and Huaping Xu
ACS BIOMATER-SCI ENG, 2018, 4, 1954-1962
Selenium is a unique, essential trace element that plays an important role in the antioxidant defense and redox regulation of biological processes. We have reported that novel selenium-containing platinum-based anticancer molecules (EG-Se/Pt) had selective cytotoxicity toward cancer cells. Herein, we found the underlying mechanism of selective cytotoxicity to be closely related to the glutathione antioxidant defense system. Elevated ROS make cancer cells more vulnerable to ...
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Multi-hierarchical Responsive Polymers: Stepwise Oxidation of a Selenium- and Tellurium-Containing Block Copolymer with Sensitivity to both Chemical and Electrochemical Stimuli
Lu Wang, Wencong Wang, Wei Cao and Huaping Xu
Polym. Chem., 2017, 8, 4520–4527
Nanomaterials with hierarchical responsiveness are of great significance for not only fundamental science but also future biomedical applications due to sophisticated and hierarchical physiological environments. Here, we report a selenium- and tellurium-containing block copolymer that can be stepwise oxidized by both chemical methods and electrochemical methods. Differences in sensitivity to the oxidation of selenium and tellurium were employed. By tuning the concentration of the oxidant and ...
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Selenium-functionalized Graphene Oxide that Can Modulate the Balance of Reactive Oxygen Species
Jiahao Xia, Feng Li, Shaobo Ji and Huaping Xu
ACS Appl. Mater. Interfaces, 2017, 9, 21413−21421
Graphene oxide (GO) is an important two-dimensional material since it is water soluble and can be functionalized to adapt to different applications. However, the current covalent functionalization methods usually require hash conditions, long duration and sometimes even multi-steps, while noncovalent functionalization is inevitably unstable, especially under physiological environment where competing species exist. Diselenide bond is a dynamic covalent bond and can respond t...
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Prof. Weibo Cai visited Tsinghua University and gave a lecture
On May 16th, 2017, Prof. Weibo Cai from University of Wisconsin - Madison, USA visited Tsinghua University and gave a lecture about “Molecular Imaging, Imaging-Guided Drug Delivery, and Theranostics”.
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Selenium-functionalized Metal-Organic Frameworks for Enzyme Mimics
Weiqiang Zhou, Hongfeng Li, Bin Xia, Wenlan Ji, Shaobo Ji, Weina Zhang, Wei Huang, Fengwei Huo and Huaping Xu
Nano Res., 2018, 11, 5761-5768
The development of artificial enzyme mimics has been rapidly growing and attracting more and more attention owing to their remarkable advantages over natural enzymes. Herein, we developed a general and facile method to fabricate an efficient glutathione peroxidase (GPx) mimic by grafting the selenium-containing molecule (phenylselenylbromide: PhSeBr) to the framework of Zr(IV)-based UiO-66-NH2 (UiO-66-Se). With glutathione (GSH) serving as the substrate...
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Diselenide-Containing Hyperbranched Polymer with Light-Induced Cytotoxicity
Chenxing Sun, Shaobi Ji, Feng Li and Huaping Xu
ACS Appl. Mater. Interfaces, 2017, 9, 12924–12929.
A light-induced cytotoxicity system was fabricated using active diselenide/porphyrin-containing hyperbranched polymer aggregates in aqueous solution through emulsification. When the nanoparticles were irradiated with visible light, 1O2 was produced by the porphyrin photosensitizers in the system, which cleaved the diselenide bonds in the polymer chains and disassembled the nanosystem. Interestingly the oxidized products exhibited cytotoxicity to the MDA-MB 231cell line without using extra antic...
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Selenium Containing Macrocycles: Transformation between Se-N/Se-S/SeSe Bonds
Shaobo Ji, Hicham El Mard, Mario Smet, Wim Dehaen and Huaping Xu
Sci. China Chem., 2017, 60, 1191-1196
Macrocycles possess potential applications in supramolecular chemistry and biosystems. Thus development of new kinds of macrocycles is of significance. Herein, novel macrocycles containing Se-Se/Se-S bonds were synthesized via transformation be-tween selenium related dynamic covalent bonds. A monomer containing two ebselen moieties was synthesized (M1). The Se-N bonds in M1 was reduced by dithiothreitol, forming Se-S linked dimer (D1). To realize the transformation from Se-S bonds to Se-Se ...
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Near-Infrared Light Stimuli-responsive Synergistic Therapy Nanoplatforms Based on the Coordination of Tellurium-containing Block Polymer and Cisplatin for Cancer Treatment
Feng Li, Tianyu Li, Wei Cao, Wang Lu and Huaping Xu
Biomaterials, 2017, 133, 208-218.
Cisplatin (CDDP) has received worldwide approval for clinical use in the past decades. However, its development in cancer chemotherapy was overshadowed by severe side effects and drug resistance. Herein, we developed a CDDP drug delivery system with high encapsulation efficiency and near-infrared light stimuli-responsive drug release properties based on the coordination of novel tellurium-containing block polymer (PEG- PUTe-PEG) and CDDP. The nanocarriers made from PEG-PUTe-PEG were loaded wit...
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Prof. Yiyun Cheng visited Tsinghua University and gave a lecture
On Feb. 20th, 2017, Prof. Yiyun Cheng from East China Normal University, China visited Tsinghua University and gave a lecture about “Rational Design of Polymers for Gene and Protein Delivery”.
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