Feng Li, Yiye Li, Xiao Yang, Xuexiang Han, Yang Jiao, Taotao Wei, Dayong Yang, Huaping Xu and Guangjun Nie Angew. Chem. Int. Ed., 2018, 57, 2377-2382 Cysteine-based chiral optically active carbon dots (CDs) and their effects on cellular energy metabolism, which is vital for essential cellular functions, have been barely reported. A green and effective synthesis strategy for chiral N-S-doped CDs (fluorescence quantum yield ca. 41.26 %) based on hydrothermal treatment of lord-cysteine at as low as 60℃ has been developed. This suggested that cysteine was instable in aqueous solutions and ac...

Tianyu Li, Wentian Xiang, Feng Li and Huaping Xu Biomaterials, 2018, 157, 17-25 It is urgently desired that self-assembly methods can be used to develop smart nanomedicines with adjustable anticancer activity and concise structure. Herein, we design carrier-free small molecule assemblies of platinum coordinated selenomethionine, which exhibit adjustable anticancer activity regulated by their self-assembly behaviors. The small molecule assemblies are prepared by coordination of selenomethionine esters with cisplatin. Their self-assembly behaviors can be tuned by esterification between sel...