Author: wanglu

Joint Group Meeting between Prof. Huaping Xu’s Group and Prof. Yi Cao’s Group

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联合组会
On March 24th, a joint group meeting was held between Prof. Huaping Xu’s Group from Tsinghua University, Prof. Yi Cao’s Group from Nanjing University and Prof. Fengwei Huo's Group from Nanjing Tech University. The meeting was chaired by Dr. Ju Guan (Xu' Group) and Dr. Fanchen Meng, consisting of twelve reports totally from three groups. Mr. Yizheng Tan, Mr. Shuojiong Pan, Mr. Peng Zhao and Mr. Yiheng Dai From our group made the oral presentation respectively. At the end of the meeting,  Prof. Huaping Xu made a summary and outlook.
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A nanotherapeutic strategy to reverse NK cell exhaustion

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Shuojiong Pan, Jun Guan, Banruo Xianyu, Yizheng Tan, Tianyu Li, and Huaping Xu Adv. Mater.; 2023, 23, 2211370. As a specialized immune effector cell, natural killer (NK) cells play a very important role in immunotherapy, but tumor immunosuppression caused by abnormal expression of cancer cells seriously weakens its therapeutic effect and leads to exhaustion. Here, we developed a self-assembled selenium containing nanoparticles (NPs) composed of Cetuximab, C5SeSeC5 and inhibitor LY345899 to reverse NK cell exhaustion. The obtained NPs can target EGFR on the surface of cancer cells and locat...
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Mechanochemistry of dynamic chalcogen-containing polymers: a minireview

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Muqing Cao, Yizheng Tan and Huaping Xu New Journal of Chemistry; 2023, 47, 5582. In recent years, mechanochemistry of polymers, which means the reactivity of polymers under mechanical stimuli, has been widely studied and greatly developed. Among various kinds of mechano-responsive polymers, dynamic chalcogen-containing polymers have attracted more attention due to their sensitive responsiveness and precise biofunction. In this perspective, we provide an overview of mechanochemistry of dynamic chalcogen-containing polymers, including both fundamental mechanochemistry and applications. Particu...
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Dynamic Fluorescent Patterning Based on Visible-Light-Responsive Diselenide Metathesis

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Jinyan Si, Peng Zhao, Jun Guan, Shaobo Ji and Huaping xu Langmuir; 2022, 38, 13272 A diselenide bond, as a dynamic covalent bond, is a versatile tool to construct smart interfaces, which can respond to visible light. In this work, we used microcontact printing (μCP) to construct diselenide patterns on quartz substrates. Fluorescent patterns were obtained on the modified surfaces via the visible-light-induced diselenide metathesis reaction, which allowed the patterning process to be fast, dynamically erasable, and compatible with different fluorescent molecules including rhodamine B and b...
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Rapidly reprogrammable actuation of liquid crystal elastomers

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Cheng Liu, Shaobo Ji and Huaping Xu Matter; 2022, 3, 2397. A rapid and reprogrammable alignment strategy for the reversible actuation of liquid crystal elastomers has been achieved through the phase-transition-induced shape memory effect. This breakthrough, recently reported in Advanced Materials by Xie and colleagues, illustrated the important role of shape-memory-induced stress regulation in developing and improving functional polymer materials.
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