Yiheng Dai, Tianyu Li, Zhiheng Zhang, Yizheng Tan, Shuojiong Pan, Luo Zhang, and Huaping Xu
J. Am. Chem. Soc., 2021, 143, 10709.
Intracellular polymerization is an emerging technique that can potentially modulate cell behavior, but remains challenging because of the complexity of the cellular environment. Herein, taking advantage of the chemical properties of organotellurides and the intracellular redox environment, we develop a novel oxidative polymerization reaction that can be conducted in cells without external stimuli. We demonstrate that this polymerization reaction is triggered by t...
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Author: wanglu
ROS-Responsive Tellurium-Containing Polymers
Shuojiong Pan, huaping Xu
Acta Polymerica Sinica, 2021, 52, 857.
Stimuli-responsive polymers are defined as polymers whose structure and properties can be changed in response to minor changes in the surrounding physical or chemical environment. In recent years, our research group pioneered in the research of ROS-responsive tellurium-containing polymers and their application in drug delivery. The work presented in this feature article, starting from the difference of oxidation responsiveness of tellurium and selenium, explored the ultra-sensitive ROS-response of tellurides. Then we studied ...
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Side-Chain Selenium-Grafted Polymers Combining Antiangiogenesis Treatment with Photodynamic Therapy and Chemotherapy
Chenxing Sun, Shiqian Gao, Yizheng Tan, Zhiheng Zhang, and Huaping Xu
ACS Biomater. Sci. Eng., 2021, 7, 3201.
The abnormal tumor vasculature in solid tumors creates hypoxia and leads to compromising the delivery and anticancer efficiency of nanomedicine. Nanomaterials with intrinsic antiangiogenesis ability might normalize tumor vessels and improve the therapeutic effect of O2-related treatment like PDT. Herein, we designed and prepared ROS-responsive side-chain selenium-grafted polymers, which had potential antiangiogenic activity, as vehicles to load photodynamic therapeutic agent Ce6 an...
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Xu’s Group Attended the 32nd CCS Congress

On April 19th-22nd 2021, Prof. Huaping Xu, Mr. Peng Zhao and Mr. Shuojiong Pan attended the 32nd CCS Congress.
Prof. Huaping Xu co-chaired Branch Venue 17: Advanced Chemistry Education.
Mr. Peng Zhao and Mr. Shuojiong Pan worked as volunteers for Branch Venue 17.
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“Reprocessable Thermosets”: Synthesis and Characterization of Vitrimer in the Undergraduate Lab Course
Qiaomei Chen, Yang Yang, Ying Yu, and Huaping Xu
J. Chem. Educ.; 2021, 98, 1429.
This article introduces a novel experiment that involves vitrimers, a new type of polymer, in polymer chemistry and physics lab courses for undergraduate students. Vitrimers are permanently cross-linked networks that can be reprocessed under certain external stimuli. Therefore, they combine the advantages of traditional thermoplastics (excellent reprocessability) with thermosets (outstanding mechanical properties and environmental stability). They can be regarded as a kind of “special thermoset”, which moves t...
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CO/chemosensitization/antiangiogenesis synergistic therapy with H2O2-responsive diselenide-containing polymer
Jichun Yang, Shuojiong Pan, Shiqian Gao, Tianyu Li, Huaping Xu
Biomaterials, 271, 120721.
Carbon monoxide (CO) therapy and antiangiogenesis therapy (AAT) are regarded as promising approaches for cancer treatment. However, the poor tumor targeting ability and inevitable side effects prevent their clinical application. In this study, we developed H2O2-responsive diselenide-containing micelles that combined CO therapy with chemosensitization therapy and AAT in a single system. Under the interaction of intratumoral
H2O2, CO and gemcitabine (GEM) were released in situ from the micelles to redu...
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Scholarships and Prizes of Xu’s group in 2020
Winners
Prizes
Jiahao Xia
Excellent Doctoral Dissertation of Tsinghua University
Chenxing Sun
Scholarship for Comprehensive Performance (First Class)
Cheng Liu
National Scholarship
Shuojiong Pan
National Scholarship
Peng Zhao
Scholarship for Comprehensive Performance (Second Class)
Peng Zhao
Best Poster Presentation Award (Doctoral Academic Forum Shimadzu Scholarship)
Yiheng Dai
Scholarship for Comprehensive Performance (Second Class)
Zhiyuan Fan
T. P. HOU AWARD
Zhiyuan Fan
Outstanding Graduate Student of Tsinghua University
Cha...
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Happy Year of the Ox
Adaptive Se-Te Metathesis Controlled by Cucurbituril-Based Host-Guest Interaction
Cheng Liu, Zhiheng Zhang, Zhiyuan Fan, Chaowei He, Yizheng Tan, Huaping Xu
Chem. Asian J.; 2020, 15, 4321.
Regulating the reactivity and equilibrium of dynamic reaction is essential for adaptive chemistry and functional materials. Herein, cucurbituril-based host-guest interaction was embedded into the dynamic metathesis between diselenide and ditelluride to establish an equilibrium-adaptive system. In this system, cucurbit[6]uril (CB[6]) selectively bound with diselenide while cucurbit[7]uril (CB[7]) bound with not only diselenide but also ditelluride and exchange product. The dynamic natu...
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Exploring the Difference of Bonding Strength Between Silver(I) and Chalcogenides in Block Copolymer Systems
Peng Zhao, Cong-Qiao Xu, Chenxing Sun, Jiahao Xia, Lin Sun, Jun Li and Huaping Xu
Polym. Chem.; 2020, 11, 7087.
Silver(I)–chalcogenide interactions have been widely found in the mineral paragenesis and are of great significance in medicinal systems. An accurate understanding of the intrinsic nature of these interactions would provide the basis for comprehending the involved natural and biological behaviors. However, few systematic works exploring the relative strength of silver(I)–chalcogenide bonds had been reported before. Thus, by combining single-molecule force spectroscopy (SMFS) from...
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