Jiahao Xia, Hongbin Li, Huaping Xu Acta Polym. Sin., 2020, 51, 205.   Sulfur, selenium-containing bonds, including disufide bond (SS), diselenide bond (SeSe), and selenide-sulfide bond (SeS), are an important type of light responsive dynamic covalent bonds. Among them, SS and SeS bonds can undergo exchange reaction with the irridiation of UV light, while SeSe bond only requires visible light due to its weaker bond energy. The purpose of this research is to use atomic force microscope-based single molecule force spectroscopy (AFM-SMFS) measurement to reveal the reasons behind the re...

Yiheng Dai, Tianyu Li, Zhiheng Zhang, Yizheng Tan, Shuojiong Pan, Luo Zhang, and Huaping Xu J. Am. Chem. Soc., 2021, 143, 10709. Intracellular polymerization is an emerging technique that can potentially modulate cell behavior, but remains challenging because of the complexity of the cellular environment. Herein, taking advantage of the chemical properties of organotellurides and the intracellular redox environment, we develop a novel oxidative polymerization reaction that can be conducted in cells without external stimuli. We demonstrate that this polymerization reaction is triggered by t...

Shuojiong Pan, huaping Xu Acta Polymerica Sinica, 2021, 52, 857. Stimuli-responsive polymers are defined as polymers whose structure and properties can be changed in response to minor changes in the surrounding physical or chemical environment. In recent years, our research group pioneered in the research of ROS-responsive tellurium-containing polymers and their application in drug delivery. The work presented in this feature article, starting from the difference of oxidation responsiveness of tellurium and selenium, explored the ultra-sensitive ROS-response of tellurides. Then we studied ...

Chenxing Sun, Shiqian Gao, Yizheng Tan, Zhiheng Zhang, and Huaping Xu ACS Biomater. Sci. Eng., 2021, 7, 3201. The abnormal tumor vasculature in solid tumors creates hypoxia and leads to compromising the delivery and anticancer efficiency of nanomedicine. Nanomaterials with intrinsic antiangiogenesis ability might normalize tumor vessels and improve the therapeutic effect of O2-related treatment like PDT. Herein, we designed and prepared ROS-responsive side-chain selenium-grafted polymers, which had potential antiangiogenic activity, as vehicles to load photodynamic therapeutic agent Ce6 an...

Qiaomei Chen, Yang Yang, Ying Yu, and Huaping Xu J. Chem. Educ.; 2021, 98, 1429. This article introduces a novel experiment that involves vitrimers, a new type of polymer, in polymer chemistry and physics lab courses for undergraduate students. Vitrimers are permanently cross-linked networks that can be reprocessed under certain external stimuli. Therefore, they combine the advantages of traditional thermoplastics (excellent reprocessability) with thermosets (outstanding mechanical properties and environmental stability). They can be regarded as a kind of “special thermoset”, which moves t...

Jichun Yang, Shuojiong Pan, Shiqian Gao, Tianyu Li, Huaping Xu Biomaterials, 271, 120721. Carbon monoxide (CO) therapy and antiangiogenesis therapy (AAT) are regarded as promising approaches for cancer treatment. However, the poor tumor targeting ability and inevitable side effects prevent their clinical application. In this study, we developed H2O2-responsive diselenide-containing micelles that combined CO therapy with chemosensitization therapy and AAT in a single system. Under the interaction of intratumoral H2O2, CO and gemcitabine (GEM) were released in situ from the micelles to redu...

Cheng Liu, Zhiheng Zhang, Zhiyuan Fan, Chaowei He, Yizheng Tan, Huaping Xu Chem. Asian J.; 2020, 15, 4321. Regulating the reactivity and equilibrium of dynamic reaction is essential for adaptive chemistry and functional materials. Herein, cucurbituril-based host-guest interaction was embedded into the dynamic metathesis between diselenide and ditelluride to establish an equilibrium-adaptive system. In this system, cucurbit[6]uril (CB[6]) selectively bound with diselenide while cucurbit[7]uril (CB[7]) bound with not only diselenide but also ditelluride and exchange product. The dynamic natu...