Jiahao Xia, Peng Zhao, Shuojiong Pan, and Huaping Xu ACS Macro Lett., 2019, 8, 629−633 Mechanophore is a kind of functional group that can undergo chemical reactions when given mechanical force stimuli. In this paper, osmotic pressure was used as an external force to trigger a diselenide exchange reaction. A diselenide bond containing block polymer capable of self-assembling to a vesicle structure and an ester bond containing a counterpart were synthesized in this study. When NaCl was added into the solution to generate the osmotic pressure difffference inside and outside vesicles, disel...

Lu Wang, Kuixin Zhu, Wei Cao, Chenxing Sun, Chenjie Lu and Huaping Xu Polym. Chem., 2019, 10, 2039 – 2046. Synthetic degradable polymers for biomedical applications have drawn considerable attention because of the nonnegligible environmental pollution and bioaccumulation caused by nondegradable synthetic polymers. We developed a new degradable reactive oxygen species (ROS) responsive selenide-containing polymer that can depolymerize controllably through selenoxide elimination reactions. β-selenylated carbonyl groups were employed in the main chains for oxidation induced degradation inste...

Wentian Xiang, Zhandong Li, Cong-Qiao Xu, Jun Li, Wenke Zhang, and Huaping Xu Chem. Asian J. 2019, 14, 1481–1486. Gold–chalcogen interactions are ubiquitous in gold biological and medicinal systems. Understanding the nature of these interactions can provide the basis for regulating their structures and functionalities and a reasonable way to interpret the differences in various properties. However, the relative strength of gold–chalcogen bonds remains controversial, and the conclusions of many related works are inconsistent. Thus, in this work, we successfully quantified the relative strengt...

Jiahao Xia, Peng Zhao, Ke Zheng, Chenjie Lu, Shouchun Yin and Huaping Xu Angew. Chem. Int. Ed., 2019, 131, 552-556. Surface modification is an important technique in fields, such as, self‐cleaning, surface patterning, sensing, and detection. The diselenide bond was shown to be a dynamic covalent bond that can undergo a diselenide metathesis reaction simply under visible light irradiation. Herein we develop this diselenide dynamic chemistry into a versatile surface modification method with a fast response and reversibility. The diselenide bond could be modified onto various substrates, su...

Fuqiang Fan, Shaobo Ji, Chenxing Sun, Cheng Liu, Ying Yu, Yu Fu and Huaping Xu Angew. Chem. Int. Ed., 2018, 57, 16426-16430. Though wavelength-controlled dynamic processes have been well developed, they mostly consist of light-triggered isomerization or the cleavage/formation of molecular connections. Control over dynamic metathesis reactions by different light wavelengths, which would be useful in controllable dynamic chemistry, has rarely been studied. Herein, taking advantage of the different bond energies of disulfide bonds and diselenide bonds, we realized a wavelength-driven exchange r...

Jiahao Xia, Tianyu Li, Chenjie Lu and Huaping Xu Macromolecules, 2018, 51, 7435-7455 Selenium is a semimetallic element lying in group XVI of the periodic table with its chemical properties resembling sulfur. But owing to its relatively low electronegativity and large atomic radius compared with sulfur, selenium also shows unique properties. This feature endows selenium-containing compounds with high reactivity and sensitivity. Although organic selenium chemistry has been developing very fast, the successful introduction of selenium into polymer science is rather scarce. Fortunately, we ...

Shaobo Ji and Huaping Xu Sci. China Chem., 2018, 10.1007/s11426-018-9352-x  

Feng Li, Dayong Yang and Huaping Xu Chem. Eur. J., 2019, 25, 1165-1176 Carbon dots (CDs) are new materials with capability in bioimaging, optical device, catalysis, and many other fields. Their advantages, such as ease of large‐scale preparation, low cost of precursor, highly tunable photoluminescence, satisfactory biocompatibility, and photostability against photobleaching, make them competitive alternatives to conventional semiconductor‐based quantum dots and organic dyes. In order to overwhelm other luminescent materials in applications, their functionalities are still needed to impro...

Xu, H.*; Chen, X.* and Kaplan, D.* ACS Biomaterials Science & Engineering, 2018, 4, 1926-1927

Feng Li, Yiye Li, Xiao Yang, Xuexiang Han, Yang Jiao, Taotao Wei, Dayong Yang, Huaping Xu and Guangjun Nie Angew. Chem. Int. Ed., 2018, 57, 2377-2382 Cysteine-based chiral optically active carbon dots (CDs) and their effects on cellular energy metabolism, which is vital for essential cellular functions, have been barely reported. A green and effective synthesis strategy for chiral N-S-doped CDs (fluorescence quantum yield ca. 41.26 %) based on hydrothermal treatment of lord-cysteine at as low as 60℃ has been developed. This suggested that cysteine was instable in aqueous solutions and ac...