Weiqiang Zhou, Lu Wang, Feng Li, Weina Zhang, Wei Huang, Fengwei Huo and Huaping Xu Adv. Funct. Mater., 2017, 27, 1605465. The development of efficient multi-responsive drug delivery systems (DDS) to control drug release has been widely explored. Herein, we report a facile strategy that enabled the micelles of the selenium-containing polymer with the drug to be encapsulated in metal-organic frameworks (MOFs), which served as multi-responsive drug release by employing the selenium-containing polymers with redox-triggered property and the MOFs with pH-triggered property in DDS. In this cas...

Jiahao Xia, Shaobo Ji and Huaping Xu Polym. Chem., 2016, 7, 6708-6713. We demonstrated the proof-of-concept that diselenide dynamic chemistry can perform at oil/water interface. The assymetric diselenide-containing polymer, which would decompose under visible light once seperated from metathesis mixture, was successfully stabilized via a micelle induced stabilization method.

Wei Cao, Feng Li, Ruofan Chen and Huaping Xu RSC Adv., 2016, 6, 94033-94037. Tellurium containing nanoparticles were designed and synthesized for the delivery of cisplatin based on coordination interaction. The tellurium containing nanomedicine could achieve betterin vivo efficacy and reduce side effects, owing to the prolonged blood circulation. This kind of approach marked a new frontier of tellurium containing nanomedicine.  

Tianyu Li, Feng Li, Wentian Xiang, Yu Yi, Yuyan Chen, Liang Cheng, Zhuang Liu and Huaping Xu ACS Appl. Mater. Interfaces, 2016, 8, 22106–22112. Selenium has attracted increasing interest in the past decades because of the function of regulating the redox balance in human body. However, biomedical studies of selenium are still limited. Gold nanoparticles (AuNPs), typically prepared by a first reduction step followed by a second stabilization step, are widely applied in biomedical studies. But their own anti-cancer activity is less studied. Here, we report 2-nm AuNPs with significant anti-...

Fuqiang Fan, Lu Wang, Feng Li, Yu Fu and Huaping Xu ACS Appl. Mater. Interfaces, 2016, 8, 17004-17010. Tellurium-containing photoresponsive polyelectrolyte multilayer films were fabricated by layer-by-layer assembly of a tellurium-containing polymer, photosensitizer, and poly(styrenesulfonate). The resulting films were investigated by UV/vis spectroscopy, XPS, EPR, and fluorescence spectroscopy. Under visible light, the photosensitizer in the film is excited and transforms triplet oxygen into singlet oxygen in aqueous solution. Singlet oxygen oxidizes −Te– to high valence state (Te═O) on...