Weiqiang Zhou, Hongfeng Li, Bin Xia, Wenlan Ji, Shaobo Ji, Weina Zhang, Wei Huang, Fengwei Huo and Huaping Xu
Nano Res., 2018, 11, 5761-5768
The development of artificial enzyme mimics has been rapidly growing and attracting more and more attention owing to their remarkable advantages over natural enzymes. Herein, we developed a general and facile method to fabricate an efficient glutathione peroxidase (GPx) mimic by grafting the selenium-containing molecule (phenylselenylbromide: PhSeBr) to the framework of Zr(IV)-based UiO-66-NH2 (UiO-66-Se). With glutathione (GSH) serving as the substrate...
More
Author: wanglu
Diselenide-Containing Hyperbranched Polymer with Light-Induced Cytotoxicity
Chenxing Sun, Shaobi Ji, Feng Li and Huaping Xu
ACS Appl. Mater. Interfaces, 2017, 9, 12924–12929.
A light-induced cytotoxicity system was fabricated using active diselenide/porphyrin-containing hyperbranched polymer aggregates in aqueous solution through emulsification. When the nanoparticles were irradiated with visible light, 1O2 was produced by the porphyrin photosensitizers in the system, which cleaved the diselenide bonds in the polymer chains and disassembled the nanosystem. Interestingly the oxidized products exhibited cytotoxicity to the MDA-MB 231cell line without using extra antic...
More
Selenium Containing Macrocycles: Transformation between Se-N/Se-S/SeSe Bonds
Shaobo Ji, Hicham El Mard, Mario Smet, Wim Dehaen and Huaping Xu
Sci. China Chem., 2017, 60, 1191-1196
Macrocycles possess potential applications in supramolecular chemistry and biosystems. Thus development of new kinds of macrocycles is of significance. Herein, novel macrocycles containing Se-Se/Se-S bonds were synthesized via transformation be-tween selenium related dynamic covalent bonds. A monomer containing two ebselen moieties was synthesized (M1). The Se-N bonds in M1 was reduced by dithiothreitol, forming Se-S linked dimer (D1). To realize the transformation from Se-S bonds to Se-Se ...
More
Near-Infrared Light Stimuli-responsive Synergistic Therapy Nanoplatforms Based on the Coordination of Tellurium-containing Block Polymer and Cisplatin for Cancer Treatment
Feng Li, Tianyu Li, Wei Cao, Wang Lu and Huaping Xu
Biomaterials, 2017, 133, 208-218.
Cisplatin (CDDP) has received worldwide approval for clinical use in the past decades. However, its development in cancer chemotherapy was overshadowed by severe side effects and drug resistance. Herein, we developed a CDDP drug delivery system with high encapsulation efficiency and near-infrared light stimuli-responsive drug release properties based on the coordination of novel tellurium-containing block polymer (PEG- PUTe-PEG) and CDDP. The nanocarriers made from PEG-PUTe-PEG were loaded wit...
More
Prof. Yiyun Cheng visited Tsinghua University and gave a lecture
On Feb. 20th, 2017, Prof. Yiyun Cheng from East China Normal University, China visited Tsinghua University and gave a lecture about “Rational Design of Polymers for Gene and Protein Delivery”.
More
Prof. Huaping Xu served for Associate Editor of ACS Biomaterials Science & Engineering
Prof. Huaping Xu has served for Associate Editor of ACS Biomaterials Science & Engineering since January 2017. ACS Biomaterials Science & Engineering was launched in 2015. The main scope of this journal is: Modeling and informatics tools for biomaterials; New biomaterials, bioinspired and biomimetic approaches to biomaterials; Biomaterial interfaces, biology and health; Manufacturing, technology and tissues in the context of biomaterials.
More
Prof. Huaping Xu was enrolled in Innovative Talents Cultivate Program (Youth Science and Technology Innovation Leader) MOST, 2016
Prof. Huaping Xu was enrolled in Innovative Talents Cultivate Program (Youth Science and Technology Innovation Leader) from Ministry of Science and Technology, 2016.
More
Congratulations! Tianyu Li received “NanoMed 2017 Best Poster Award” in 2017 Nano Med Conference
Tianyu Li gave a 2 min oral presentation and a poster presentation of “Selenium-containing Amphiphiles Reduced and Stabilized Gold Nanoparticles: Kill Cancer Cells via Reactive Oxygen Species” on the 2nd International Symposium on Translational Nanomedicine, Guangzhou, China from Jan.5th to Jan.7th, 2017. He got the award of “NanoMed 2017 Best Poster Award” presented by the committee of NanoMed 2017.
More
Prof. Tianfeng Chen visited Tsinghua University and gave a lecture
On Nov. 11th, 2016, Prof. Tianfeng Chen from Jinan University, China visited Tsinghua University and gave a lecture about “Multifunctional Nanomedicine: Targeted Design, Tumor Diagnosis and Treatment”.
More
Selenium-containing Polymer@Metal-organic Frameworks Nanocomposites as an Efficient Multi-responsive Drug Delivery System
Weiqiang Zhou, Lu Wang, Feng Li, Weina Zhang, Wei Huang, Fengwei Huo and Huaping Xu
Adv. Funct. Mater., 2017, 27, 1605465.
The development of efficient multi-responsive drug delivery systems (DDS) to control drug release has been widely explored. Herein, we report a facile strategy that enabled the micelles of the selenium-containing polymer with the drug to be encapsulated in metal-organic frameworks (MOFs), which served as multi-responsive drug release by employing the selenium-containing polymers with redox-triggered property and the MOFs with pH-triggered property in DDS. In this cas...
More